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found that exogenous α-KG mimics glutaminase-mediated ferroptosis, while using a transaminase inhibitor, amino-oxyacetate (AOA), reverses ferroptosis [85, 86]

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This MC-mediated pathway is thought to be one of the mechanisms underlying migraine pain pathophysiology, and migraine is one of the most common comorbidities noted in patients with MCAS [26]