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Using an enzyme cycling method, we have previously reported that Acyl-C accumulates and the ratio of free carnitine/Acyl-C is decreased only in stage 5 chronic kidney disease (CKD) patients without diabetes (34)

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These results were consistent with the findings of elevated urinary levels of the marker of lipid peroxidation, isoprostane F 2 α -VI, the marker of platelet activation, 2,3-dinor-thromboxane B 2 , and the marker of endothelial activation, 6-keto-prostaglandin F 1 α in 26 children diagnosed with ASD [117]